The carcinogenicity of creosote oil: the induction of lung tumors in mice.

ment of skin tumors in untreated mice (18) and also increased the susceptibility of mice to the in duction of skin tumors (5). Therefore, creosote was tested and found both to increase the percentage of mice bearing lung tumors and the number of ade nomas borne by individual mice over the control level. In the first experiment creosote was applied to the skin of weanling mice repeatedly in quantities sufficient to cause both skin and lung tumors to appear. In the second experiment the quantity of creosote applied to the skin, though insufficient to cause skin tumors, was nevertheless effective in giving rise to lung tumors.